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Brandon Johnson — Certified Personal Trainer, Nutrition Coach & Peptide Research Consultant
Brandon Johnson is a certified personal trainer, nutrition coach, and peptide research consultant with a background in kinesiology and over 15 years of experience in fitness and wellness. He reviews all PSPeptides educational content for scientific accuracy and practical relevance.
Mazdutide (IBI362) is a dual GLP-1/glucagon receptor agonist developed by Innovent Biologics in collaboration with Eli Lilly that has generated significant research interest as the next wave of metabolic peptides reaches Phase 3. Like survodutide, mazdutide pairs GLP-1 receptor agonism (appetite suppression, glucose control) with glucagon receptor agonism (hepatic fat oxidation, increased energy expenditure) — but with its own unique pharmacological profile, dosing characteristics, and clinical data from the GLORY Phase 3 program. PSPeptides now carries research-grade mazdutide at 99%+ independently verified purity, making it one of the few US vendors offering this emerging dual agonist.
This guide covers everything researchers need to know about mazdutide: the dual-agonist mechanism, how it differs from survodutide and retatrutide, the GLORY trial data, dosing protocols, and how PSPeptides’ verified-quality mazdutide supports cutting-edge metabolic research.
What Is Mazdutide? The Dual Agonist Mechanism
Mazdutide works by simultaneously activating two metabolic receptors: the GLP-1 receptor (GLP-1R) and the glucagon receptor (GCGR). The GLP-1 component reduces appetite through central satiety signaling, slows gastric emptying, and enhances glucose-dependent insulin secretion — the same mechanism that makes semaglutide (Ozempic) effective. The glucagon component adds what GLP-1 mono-agonists lack: direct stimulation of hepatic fat oxidation (the liver actively burns stored fat as fuel) and increased basal energy expenditure through thermogenesis. This dual pathway — reduced intake PLUS increased expenditure — is the theoretical advantage of glucagon-containing agonists like mazdutide over GLP-1-only compounds.
Mazdutide shares this dual GLP-1/glucagon mechanism with survodutide (Boehringer Ingelheim’s dual agonist). Both target the same two receptors. The differences lie in molecular design, pharmacokinetic profile, dosing schedule, and clinical program design. The survodutide guide covers the comparator compound.
Mazdutide: The GLORY Phase 3 Program
Mazdutide’s clinical development is anchored by the GLORY Phase 3 program — a series of randomized, controlled trials evaluating efficacy and safety across obesity and type 2 diabetes populations. Published Phase 3 data from GLORY-1 documented significant weight loss with mazdutide versus placebo. The GLORY program also investigates mazdutide’s effects on hepatic steatosis (fatty liver), glycemic control, and cardiometabolic risk factors — reflecting the growing understanding that next-generation metabolic peptides must address the entire metabolic syndrome, not just body weight.
Mazdutide vs Retatrutide vs Survodutide: Where It Fits
| Factor | Mazdutide | Survodutide | Retatrutide |
|---|---|---|---|
| Developer | Innovent / Eli Lilly | Boehringer Ingelheim | Eli Lilly |
| Receptors | GLP-1 + Glucagon | GLP-1 + Glucagon | GIP + GLP-1 + Glucagon |
| Agonist type | Dual | Dual | Triple |
| GIP component | ❌ | ❌ | ✅ |
| Clinical program | GLORY (Phase 3) | SYNCHRONIZE (Phase 3) | TRIUMPH (Phase 3) |
| Weight loss (Phase 3) | Significant | ~19% | 28.3% |
| PSPeptides | Buy Mazdutide | Buy Survodutide | From $39.99 |
Buy Mazdutide at PSPeptides
PSPeptides carries research-grade mazdutide at 99%+ independently verified purity with batch-specific COAs. US manufactured in New Jersey. Same-day processing seven days a week including Sundays. Free shipping on every domestic order. Afterpay at zero fees. PSPeptides is one of the only US vendors offering mazdutide alongside the complete metabolic peptide lineup: retatrutide from $39.99, survodutide, tirzepatide from $54.99, and MOTS-C from $69.99. The weight loss guide covers the full metabolic landscape. The retatrutide guide covers the triple-agonist comparator. PubMed indexes mazdutide clinical data. Wikipedia covers mazdutide.
PSPeptides: US-Made, Independently Verified, 24/7 Support
PSPeptides — US peptide manufacturer, New Jersey. 99%+ batch-specific purity verified by independent third-party HPLC/MS. Same-day processing 7 days including Sundays. Free shipping every domestic order. Zero fees on Affirm, Afterpay, Zelle, cards, Apple/Google Pay. Discrete plain white mailers. BAC water ($19.99), syringes, alcohol pads in one checkout. Free calculator. 24/7 support: live chat, email [email protected], phone (551) 284-2670. 5-star thousands of verified customers at pspeptides.com/shop.
Understanding mazdutide is essential for researchers navigating this rapidly evolving field in 2026.
Frequently Asked Questions
What is mazdutide?
A dual GLP-1/glucagon receptor agonist developed by Innovent Biologics with Eli Lilly. Same dual mechanism as survodutide. Phase 3 GLORY program. Available at PSPeptides.
Does PSPeptides sell mazdutide?
Yes. Research-grade mazdutide at 99%+ independently verified purity. US manufactured, free shipping, same-day processing, Afterpay at zero fees.
Is mazdutide better than retatrutide?
Retatrutide activates 3 receptors (GIP+GLP-1+glucagon) vs mazdutide’s 2 (GLP-1+glucagon) and produced 28.3% Phase 3 weight loss. PSPeptides carries both for comparative research.
How does mazdutide work?
Dual agonism: GLP-1 receptor (appetite suppression) + glucagon receptor (hepatic fat oxidation, increased energy expenditure). Same dual mechanism as survodutide.
All PSPeptides products are sold exclusively for research and laboratory use.