Buy 5-Amino-1MQ online in seconds: select your vial size above and add to cart. Orders placed before 2 PM EST ship the same day, and orders over $200 ship free by UPS 2nd Day Air. Sold strictly for laboratory research use.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a cell-permeable small molecule that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme concentrated in fat and liver tissue. NNMT consumes the universal methyl donor SAM to convert nicotinamide into 1-methylnicotinamide, draining the NAD+ precursor pool. Blocking NNMT preserves both SAM and NAD+ for energy-producing pathways, which is why laboratories buy 5-Amino-1MQ for obesity, metabolic-rate, and longevity models.
Unlike most compounds in our catalog, 5-Amino-1MQ is not an amino-acid chain, but it is studied alongside metabolic peptides so often that it has become a staple of research panels. Our complete guide to peptides and our best peptides for weight loss research guide explain where it fits in the wider field before you buy 5-Amino-1MQ.
Detailed Mechanism of Action
NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH). Because nicotinamide is the main substrate for NAD+ salvage, every molecule that NNMT methylates is one that can no longer be recycled into NAD+. In obese adipose tissue NNMT expression is sharply elevated, turning fat cells into a methyl sink that depletes both SAM and NAD+.
5-Amino-1MQ is a product-mimetic inhibitor: its quinolinium ring resembles the methylated product and competes for the nicotinamide-binding pocket of NNMT. Because it is small and membrane-permeable, it enters cells without a transporter and inhibits NNMT in the low-micromolar range (IC50 of roughly 1 µM) with selectivity over related methyltransferases. These properties are the reason researchers buy 5-Amino-1MQ instead of older, less selective NNMT inhibitors.
Downstream, greater NAD+ availability supports SIRT1 activity, which deacetylates PGC-1alpha and drives mitochondrial biogenesis and fatty-acid oxidation. Greater SAM availability feeds polyamine synthesis, an energy-consuming futile cycle that raises adipocyte oxygen consumption. Together these effects explain why NNMT inhibition increases cellular energy expenditure without changing food intake in animal models.
In cultured adipocytes, 5-Amino-1MQ treatment has been reported to lower 1-MNA output, raise intracellular NAD+ and SAM, and reduce lipogenesis. Laboratories that buy 5-Amino-1MQ typically use 1-MNA as the readout for target engagement, since falling 1-MNA confirms the enzyme is being blocked.
Published Research
Researchers who buy 5-Amino-1MQ are building on a decade of peer-reviewed NNMT literature. The scientific case for NNMT inhibition began with Kraus et al. (Nature, 2014), who showed that knocking down NNMT in adipose tissue and liver protected mice against diet-induced obesity by increasing energy expenditure, raising adipose SAM and NAD+, and boosting polyamine flux. That paper established NNMT as a drug target for obesity.
Neelakantan and colleagues at the University of Texas Medical Branch then developed selective quinolinium inhibitors, publishing the structure-activity relationship in the Journal of Medicinal Chemistry (2017). That work identified the quinolinium scaffold behind 5-Amino-1MQ, with low-micromolar potency and predicted binding in the NNMT substrate pocket.
In the follow-up study, Neelakantan et al. (Biochemical Pharmacology, 2018), systemic treatment of diet-induced obese mice with the membrane-permeable NNMT inhibitor significantly reduced body weight, white adipose mass, adipocyte size, and total plasma cholesterol. Food intake did not change, and no adverse effects were observed.
The muscle data are equally notable. In Neelakantan et al. (2019), 24-month-old mice dosed at 5 or 10 mg/kg after muscle injury showed elevated muscle stem cell proliferation, nearly two-fold greater myofiber cross-sectional area, and roughly 70% higher peak torque than controls.
In Dimet-Wiley et al. (Scientific Reports, 2024), eight weeks of daily 5-amino-1-methylquinolinium in 22-month-old mice raised forelimb grip strength by about 40% on its own, versus 20% for exercise alone and 60% for the combination. The authors described the effect as additive, and over 75% of the proteins shifted by the inhibitor moved in the same direction as exercise.
All of this work is preclinical, performed in mice and cell culture, and no human safety or efficacy has been established. Researchers who buy 5-Amino-1MQ should treat the literature as hypothesis-generating. Our longevity and anti-aging research guide and muscle growth and recovery guide cover the related peptide literature.
Who Buys 5-Amino-1MQ?
Three groups account for most orders. Academic and contract laboratories studying obesity and metabolic disease buy 5-Amino-1MQ as a reference NNMT inhibitor for diet-induced obesity models. Aging and longevity researchers order it for NAD+ biology and muscle stem cell work. Independent research groups building comparative metabolic panels add it alongside peptides such as MOTS-c to compare mechanisms side by side.
Whatever the application, the purchasing criteria are the same: verified purity, batch-level documentation, dependable stock, and fast domestic shipping. PSPeptides was built around exactly those requirements, which is why so many laboratories buy 5-Amino-1MQ from us more than once.
5-Amino-1MQ vs Alternatives
Researchers comparing metabolic research compounds often weigh 5-Amino-1MQ against MOTS-c and AOD-9604, both also available from PSPeptides. The table below shows where each one fits.
| Feature | 5-Amino-1MQ | MOTS-c | AOD-9604 |
|---|
| Compound type | Small molecule (quinolinium salt) | Mitochondrial-derived peptide (16 amino acids) | Modified growth hormone fragment 176-191 |
| Primary target | NNMT enzyme | AMPK and mitochondrial signaling | Lipolysis signaling |
| Core research focus | Fat mass, energy expenditure, aged muscle | Metabolic homeostasis, exercise capacity | Fat metabolism without growth effects |
| Best-known models | Diet-induced obese and 22-24-month-old mice | Insulin-resistance and exercise models | Obese rodent models and early human trials |
| Stability | Robust small molecule, tolerates transit | Peptide, keep cold | Peptide, keep cold |
| Reconstitution | Bacteriostatic water, dissolves readily | Bacteriostatic water | Bacteriostatic water |
| Vial sizes at PSPeptides | 5mg and 10mg | See product page | See product page |
| Common stack partner | MOTS-c, NAD+ precursors | 5-Amino-1MQ | GLP-1 class peptides |
For details on the alternatives, read our MOTS-c mitochondrial peptide guide and AOD-9604 research guide. Many labs buy 5-Amino-1MQ and MOTS-c together because the two act on different points of the same energy-metabolism network.
Experimental Design Considerations
The published rodent work used systemic dosing in the 5-10 mg/kg range for muscle studies, with daily administration over one to eight weeks. Cell-culture studies typically run concentration-response series in the low-micromolar range. Plan your purchase around the total milligrams your protocol requires, since reconstituted solution has a limited shelf life. Most rodent studies buy 5-Amino-1MQ in the 10mg size for this reason.
Useful readouts include plasma or media 1-MNA (target engagement), intracellular NAD+/NADH and SAM/SAH ratios (pathway effect), and endpoint measures such as body weight, adipose mass, adipocyte size, myofiber cross-sectional area, and grip strength. Include a vehicle control that matches your diluent, and record batch numbers from your COA so results can be traced to a specific lot.
Because 5-Amino-1MQ is a small molecule, it is more forgiving of transit temperature and handling than peptide compounds, but it should still be protected from light and moisture. If your experiment pairs it with peptides, order everything in one shipment so all compounds arrive from the same tested inventory. Researchers who buy 5-Amino-1MQ online from PSPeptides can combine it with any product in our catalog in a single order.
Reconstitution & Handling
5-Amino-1MQ is water-soluble and reconstitutes easily. For a 5mg vial, add 1 mL of bacteriostatic water for a 5 mg/mL stock, or 2.5 mL for 2 mg/mL. For a 10mg vial, add 2 mL for 5 mg/mL or 5 mL for 2 mg/mL. Inject the diluent slowly down the inside wall of the vial and swirl gently; do not shake.
Use sterile technique, a fresh syringe, and alcohol-swabbed stoppers for every withdrawal. Our reconstitution guide walks through the full procedure, and our dosage calculator guide handles the concentration math for any volume. New to diluents? Start with what is bacteriostatic water.
Label every reconstituted vial with the date, diluent volume, and resulting concentration. If you buy 5-Amino-1MQ in the 10mg size for a longer protocol, consider aliquoting the solution to avoid repeated stopper punctures and contamination risk.
Storage & Stability
Lyophilized 5-Amino-1MQ is a robust small molecule. Store sealed vials at -20°C for long-term stability of 12 months or more, or at 2-8°C for short-term storage. Brief room-temperature exposure during shipping does not compromise the powder, a practical advantage over peptide-based compounds.
Once reconstituted, keep the solution refrigerated at 2-8°C, protected from light, and use it within about 30 days for best results. Avoid repeated freeze-thaw cycles. Our peptide storage guide and guide to spotting degradation explain the warning signs of a compromised solution. When in doubt, buy 5-Amino-1MQ fresh rather than risk a compromised experiment.
Certificate of Analysis
Every batch of 5-Amino-1MQ sold by PSPeptides is tested by an independent third-party laboratory. HPLC quantifies purity and mass spectrometry confirms molecular identity. The resulting COA is tied to the batch number printed on your vial, not a product-line average, and batches that fall below 99% purity are never released for sale.
When you buy 5-Amino-1MQ from us, you can request the COA for your specific batch before or after ordering. If you are new to reading these reports, our guide to reading a COA explains HPLC peak data and mass-spec identity confirmation.
Quality Control at PSPeptides
Quality control starts before testing. Each 5-Amino-1MQ batch is manufactured in the United States, sealed under controlled conditions, and assigned a lot number that follows it from synthesis to your lab bench. Vials are stored frozen in our facility until the day they ship, so the powder you receive has never sat on a warm shelf.
Independent testing then confirms what the label says. This batch-level accountability is why researchers who buy 5-Amino-1MQ from PSPeptides can cross-reference their exact vial against its own data, and why our reorder rate on this product is among the highest in the cellular energy category.
Why Researchers Choose PSPeptides
- US Manufactured: Full batch traceability from synthesis to your lab bench.
- Third-Party Tested: Independent HPLC and mass spectrometry on every batch, 99%+ purity guaranteed.
- Fast Shipping: Free UPS 2nd Day Air over $200, same-day dispatch before 2 PM EST.
- Flexible Payments: Credit cards, Afterpay, Klarna, Apple Pay, Google Pay.
- 7-Day Support: Email, phone, or text.
Where you buy 5-Amino-1MQ matters as much as the molecule itself, because purity and handling determine whether your results are reproducible. Here is how PSPeptides compares with the alternatives researchers typically encounter.
| Feature | PSPeptides | Unverified Online Sellers | Overseas Bulk Sources |
|---|
| Batch-specific COA | Included | Inconsistent | Rarely |
| Third-party testing | Every batch | Often unverified | Unknown |
| Manufacturing origin | USA | Undisclosed | Overseas |
| Shipping | Same-day, free 2nd Day Air over $200 | Varies | Weeks, customs risk |
| Support | 7 days a week | Limited | None |
Our guide to choosing a research peptide supplier lists the questions to ask any vendor before you buy 5-Amino-1MQ or any other research compound.
Common Mistakes to Avoid Before You Buy 5-Amino-1MQ
The most common sourcing mistake is accepting a listing’s stated purity without a batch-specific Certificate of Analysis. A generic product-line COA tells you nothing about the vial in your hand. Always confirm that batch-level testing is available before you buy 5-Amino-1MQ from any vendor.
The second mistake is ordering too little. Researchers often buy 5-Amino-1MQ in a single 5mg vial, run a pilot, and then discover the follow-up protocol needs several times that amount from a different batch. Estimate your full study requirement first, and order the 10mg size or multiple vials from one batch to keep lots consistent.
The third is poor handling on arrival: leaving the vial at room temperature for weeks, reconstituting with tap or distilled water instead of bacteriostatic water, or shaking the vial. Review the storage and reconstitution guidance above before your order arrives so no material is wasted.
How to Order 5-Amino-1MQ
When you buy 5-Amino-1MQ from PSPeptides, ordering takes under a minute. Choose the 5mg or 10mg vial from the size selector above, click Add to Cart, and check out with your preferred payment method. Orders placed before 2 PM EST ship the same business day with tracking, and orders over $200 ship free by UPS 2nd Day Air.
Value improves with volume. The 10mg vial lowers your cost per milligram, and combining vials or adding other compounds to reach the $200 free-shipping threshold lowers it further. Labs that buy 5-Amino-1MQ online on a recurring basis can contact support to arrange standing orders so every reorder comes from fresh, tested inventory.
Running a multi-compound protocol? Buy 5-Amino-1MQ online together with MOTS-c, NAD+ precursors, or other metabolic research compounds in a single order to qualify for free shipping. Our peptide stacking guide covers design principles for side-by-side compound panels. For bulk or institutional pricing, contact support by email, phone, or text.
Frequently Asked Questions
Where can I buy 5-Amino-1MQ in the USA?
You can buy 5-Amino-1MQ directly from PSPeptides, a US-based supplier with domestic manufacturing, independent third-party testing, and batch-specific COAs. Choose your vial size above and order online; most domestic orders arrive within two to three business days.
Which vial size should I buy?
The 5mg vial suits cell-culture work and short pilot studies. The 10mg vial is more economical per milligram for extended rodent protocols or multi-arm experiments, and most labs that buy 5-Amino-1MQ for animal work choose it. Both sizes contain the same compound at the same verified purity.
Is 5-Amino-1MQ a peptide?
No. It is a small organic molecule, not an amino-acid chain. It is sold alongside peptides because it targets the same metabolic and longevity pathways, and it is reconstituted and handled in much the same way.
How is purity verified when I buy 5-Amino-1MQ from PSPeptides?
Each batch is sent to an independent laboratory for HPLC purity analysis and mass-spectrometry identity confirmation. The results are compiled into a Certificate of Analysis tied to your vial’s batch number, and batches below 99% purity are rejected.
How fast will my order ship?
Orders placed before 2 PM EST ship the same business day. Orders over $200 receive free UPS 2nd Day Air; smaller orders ship by standard tracked carriers. You will receive tracking by email as soon as the label is created.
Is it legal to buy 5-Amino-1MQ for research?
5-Amino-1MQ is sold as a research chemical for laboratory use only and is not approved for human or veterinary use. Our research compound legality overview covers the current regulatory landscape in the United States.
Can I buy 5-Amino-1MQ online in bulk?
Yes. Add multiple vials to your cart, or contact support for institutional and bulk pricing. Combined orders over $200 ship free, and every vial in a bulk order comes from the same tested batch whenever possible.
How does 5-Amino-1MQ compare to NMN or NR?
NAD+ precursors such as NMN and NR feed raw material into the NAD+ salvage pathway, while 5-Amino-1MQ slows the enzyme that drains it. The two approaches act at different points in the same network, which is why many labs study them in combination.
What should I check before I buy 5-Amino-1MQ from any vendor?
Confirm that the vendor provides a batch-specific Certificate of Analysis, discloses manufacturing origin, and offers documented third-party testing rather than marketing claims alone. PSPeptides meets all three criteria on every 5-Amino-1MQ order.
Related Resources
All PSPeptides products, including 5-Amino-1MQ, are sold exclusively for laboratory and research use. Not intended for human consumption.
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