5-Amino-1MQ is a cell-permeable small molecule studied for its ability to inhibit nicotinamide N-methyltransferase (NNMT), an enzyme concentrated in adipose and liver tissue that consumes the methyl donor SAM. Researchers use it to study NNMT’s role in cellular energy metabolism, methyl-donor availability, and fat-cell signaling in preclinical models.
Unlike many items in our catalog, 5-Amino-1MQ is not a peptide chain but a small organic molecule, which is why it is often studied alongside peptide-based metabolic compounds rather than in place of them. For background on how compounds like this are classified within the broader field, see our complete guide to peptides and our peptide glossary.
Academic and independent laboratories studying obesity, metabolic rate, and cellular aging frequently include NNMT inhibitors like 5-Amino-1MQ in their compound panels. It is commonly paired with mitochondrial-support compounds when researchers want to compare energy-metabolism pathways side by side, such as our MOTS-c mitochondrial peptide guide.
Detailed Mechanism of Action
NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH). Because SAM is a shared methyl donor used throughout cellular metabolism, elevated NNMT activity in adipose and liver tissue can draw down the local methyl-donor and NAD+ pools available for other pathways.
Researchers studying 5-Amino-1MQ are generally interested in whether reversibly inhibiting NNMT can shift this balance, preserving more SAM and NAD+ for energy-related metabolic processes inside fat and liver cells. This is why the compound shows up frequently in cellular energy and metabolic-rate research rather than in areas unrelated to methyl-donor biology.
Because NNMT sits at the intersection of the methionine cycle and NAD+ salvage pathway, inhibiting it can theoretically influence both pathways at once. Cell-culture studies typically look at 1-MNA output as an indirect marker of NNMT activity, since lower 1-MNA production suggests the enzyme is being effectively blocked.
Some research teams also examine downstream effects on SIRT1 signaling, since NAD+ availability is closely tied to sirtuin activity in metabolic tissue. This has made 5-Amino-1MQ a compound of interest for labs already working with NAD+ precursors or other longevity-adjacent research molecules.
Some laboratories also track downstream markers such as PGC-1alpha expression or mitochondrial biogenesis indicators when studying NNMT inhibition, since these are commonly used proxies for shifts in cellular energy metabolism in preclinical models.
Because 5-Amino-1MQ is a small, cell-permeable molecule rather than a peptide, it is often studied alongside peptide-based metabolic research compounds to compare mechanisms across pathway types. Some labs pair NNMT-inhibition studies with broader metabolic research panels to see how different pathways interact under the same experimental conditions.
All of this work remains preclinical and investigational. PSPeptides makes no claims about outcomes in humans, and this vial is sold exclusively for qualified laboratory research. Buy 5-Amino-1MQ only when you have a legitimate laboratory research need for it.
Published Research
Interest in NNMT as a metabolic research target traces back to earlier academic work on NNMT knockdown in adipose tissue, which reported effects on diet-induced weight gain in mouse models. Follow-on work from research groups developing selective small-molecule NNMT inhibitors, including compounds in the amino-methylquinolinium class, has examined similar endpoints such as fat mass and metabolic markers in high-fat-diet mouse models.
Additional cell-culture and rodent work has looked at NNMT inhibition in the context of skeletal muscle and age-related decline, exploring whether restoring methyl-donor balance affects markers of cellular senescence. These findings remain preliminary and are specific to the animal and cell-culture models used. Researchers who buy 5-Amino-1MQ for this type of work should treat all findings as hypothesis-generating rather than conclusive.
This body of research is early-stage, primarily conducted in animal and cell-culture models, and has not established safety or efficacy in humans. Researchers can review the primary literature directly through PubMed rather than relying on secondary summaries: NNMT inhibitor research on PubMed, 5-Amino-1MQ studies on PubMed, and NNMT and adipose metabolism on PubMed.
Because interest in NNMT inhibitors has grown alongside broader NAD+ and longevity research, more labs are requesting 5-Amino-1MQ specifically to include in comparative metabolic panels rather than as a standalone study compound.
5-Amino-1MQ vs Other Sourcing Options
Where you buy 5-Amino-1MQ matters just as much as the molecule itself, since purity and handling directly affect research reproducibility. The table below compares PSPeptides against two common alternative sourcing paths researchers encounter.
| Feature |
PSPeptides |
Unverified Online Sellers |
Informal/DIY Sources |
| Third-Party Testing |
Yes, every batch |
Often unverified |
Rarely available |
| Certificate of Analysis |
Included per batch |
Inconsistent |
Not typically provided |
| US Manufacturing |
Yes |
Varies / unclear origin |
Unknown origin |
| Batch Traceability |
Full traceability |
Limited |
None |
| Customer Support |
7 days a week |
Varies |
None |
| Shipping Speed |
Free 2nd Day Air over $200 |
Varies |
N/A |
For general guidance on evaluating any supplier, not just PSPeptides, see our guide to choosing a research peptide supplier.
Reconstitution & Handling
Researchers typically reconstitute lyophilized 5-Amino-1MQ using bacteriostatic water and standard sterile-lab technique, adding the diluent slowly down the inside wall of the vial rather than directly onto the powder. Our reconstitution guide and dosage calculator walk through the lab math for common dilution ratios. For background on the diluent itself, see what is bacteriostatic water.
Swirl the vial gently rather than shaking it, since agitation and excess heat can stress the molecule’s structure. Once reconstituted, the solution should be handled with the same sterile precautions used for any laboratory reagent, including clean workspace surfaces and sterile syringes for withdrawal.
Label reconstituted vials with the dilution date and ratio used, since this recordkeeping is essential for reproducible lab results across a research project.
Storage & Stability
Store the lyophilized vial in a freezer, protected from light, until you are ready to reconstitute. Left in powder form and properly sealed, stability is generally maintained far longer than after reconstitution.
After reconstitution, keep the vial refrigerated and shielded from direct light to help preserve stability, and avoid repeated freeze-thaw cycles. Our peptide storage guide covers general stability windows and handling best practices for reconstituted research compounds. Buy 5-Amino-1MQ in a quantity you can reasonably use within its stable window.
Certificate of Analysis
Every batch of 5-Amino-1MQ sold by PSPeptides includes a Certificate of Analysis generated by an independent third-party laboratory, confirming identity and purity through HPLC and mass spectrometry. The COA is tied to the specific batch number on your vial, not a generic product-line average. Buy 5-Amino-1MQ with confidence knowing the COA is available for review.
If you’re new to reading these reports, our guide to reading a COA explains what each section means, including how to interpret HPLC peak data and mass spec identity confirmation.
Research Use & Sourcing Considerations
Regulatory frameworks around research compounds continue to evolve, and it’s worth staying current on how they’re classified. Our research peptide legality overview and research vs. prescription compounds guide provide helpful background for laboratory purchasers.
How 5-Amino-1MQ Fits Into a Research Stack
Labs studying cellular energy metabolism often run 5-Amino-1MQ alongside other mitochondrial or NAD+-related compounds to compare pathway-level effects. If you buy 5-Amino-1MQ for a multi-compound protocol, our peptide stacking guide covers general principles researchers use when designing side-by-side compound panels.
Because 5-Amino-1MQ targets a distinct enzymatic pathway from most peptide hormones, it is frequently treated as a complementary research tool rather than a substitute for peptide-based protocols already in use in a lab. Many labs buy 5-Amino-1MQ specifically for this complementary role.
Shelf Life & Degradation
Like other lab compounds, 5-Amino-1MQ can degrade if exposed to excess heat, light, or moisture, which is why proper freezer storage before reconstitution matters. Our guide to spotting compound degradation outlines visual and practical cues researchers use to check whether a solution has broken down.
For a broader reference on how stability windows vary across different research compounds, see our peptide half-life chart. When in doubt, order a fresh vial rather than relying on a solution past its expected stability window.
Handling & Documentation Best Practices
Because 5-Amino-1MQ is sold strictly for laboratory research, PSPeptides recommends following standard lab safety protocols: gloves, eye protection, and a clean workspace when handling the lyophilized powder or reconstituted solution. Keep material safety documentation and your COA on file with your lab records for every batch you buy.
Researchers new to sourcing lab compounds may also find it useful to review general background on how research-only compounds differ from clinically approved products; our research vs. prescription compounds guide covers this distinction in more detail. Buy 5-Amino-1MQ only for legitimate laboratory purposes consistent with these guidelines.
5-Amino-1MQ Compared to NAD+ Precursors
Researchers sometimes ask how 5-Amino-1MQ relates to well-known NAD+ precursors like NMN or NR. Precursors work by directly feeding the NAD+ salvage pathway with raw material, while 5-Amino-1MQ takes a different route, inhibiting NNMT so that existing SAM and NAD+ pools are consumed more slowly by methylation reactions.
Because the two approaches act on different points in the same broader metabolic network, some labs studying NAD+ biology choose to buy 5-Amino-1MQ specifically to test it in combination with precursor compounds, rather than as a direct replacement for them. Buy 5-Amino-1MQ specifically when your protocol calls for NNMT inhibition rather than direct NAD+ precursor supplementation.
Quality Control at PSPeptides
Every 5-Amino-1MQ batch moves through an identity and purity screening process before it is approved for sale. Independent third-party labs run HPLC to quantify purity and mass spectrometry to confirm molecular identity, and the resulting data is compiled into the batch’s Certificate of Analysis.
Vials that do not meet the 99%+ purity threshold are not released for sale. This batch-level accountability is part of why researchers who buy 5-Amino-1MQ from PSPeptides can cross-reference their specific vial against its own testing data rather than a generic product average. It is one more reason researchers choose to buy 5-Amino-1MQ from a vendor with transparent batch-level testing.
Who This Product Is For
This listing is intended for qualified laboratory personnel, academic researchers, and licensed research organizations conducting in-vitro or preclinical work. It is not intended for personal use, self-experimentation, or any human or veterinary application.
If you are unsure whether your use case qualifies as research use, PSPeptides support can point you toward relevant documentation, but cannot provide medical or dosing guidance of any kind.
Common Mistakes to Avoid Before You Buy 5-Amino-1MQ
The most common sourcing mistake is skipping the Certificate of Analysis entirely and assuming a listing’s stated purity is accurate without independent verification. Always confirm that a batch-specific COA is available before you buy 5-Amino-1MQ from any vendor, not just a generic product-line document.
Another frequent issue is improper storage after the vial arrives: leaving lyophilized powder at room temperature for extended periods, or leaving reconstituted solution unrefrigerated, can shorten its usable stability window. Reviewing the storage guidance above before your order arrives helps avoid wasted material.
Finally, researchers sometimes overlook checking whether a vendor discloses manufacturing origin at all. PSPeptides discloses that 5-Amino-1MQ sold on this listing is US manufactured, which supports easier batch traceability compared to vendors who do not disclose sourcing.
Ordering & Support
When you buy 5-Amino-1MQ from PSPeptides, your order ships with tracking, temperature-conscious packaging, and access to the batch’s Certificate of Analysis. Most US orders placed before 2 PM EST go out same-day, with free 2nd Day Air shipping on orders over $200.
Have a question before you buy 5-Amino-1MQ, or need help locating a COA for a past order? PSPeptides support is available seven days a week by email, phone, or text to help with sourcing and documentation questions.
Why Buy 5-Amino-1MQ From PSPeptides
- US Manufactured
- Third-Party Tested: Independent HPLC and mass spectrometry on every batch
- Fast Shipping: Free UPS 2nd Day Air over $200, same-day before 2 PM EST
- Flexible Payments: Credit cards, Afterpay, Klarna, Apple Pay, Google Pay
- 7-Day Support: Email, phone, or text
When you buy 5-Amino-1MQ from PSPeptides, you get full batch traceability, a real COA, and a support team that can answer sourcing and handling questions directly.
Frequently Asked Questions
What is 5-Amino-1MQ used for in research?
Researchers use 5-Amino-1MQ mainly to study NNMT inhibition and its downstream effects on methyl-donor availability, NAD+ balance, and fat-cell signaling in preclinical models. It is sold strictly for laboratory research and is not approved for human use. Always buy 5-Amino-1MQ from a vendor that discloses this clearly.
How do researchers typically reconstitute this vial?
Most labs reconstitute the lyophilized powder with bacteriostatic water using sterile technique, then store the solution refrigerated. Buy 5-Amino-1MQ from a source that can also point you toward clear reconstitution documentation. See the reconstitution guide linked above for common lab dilution methods.
What purity does PSPeptides guarantee when I buy 5-Amino-1MQ?
Every vial is manufactured in the US and independently tested, with a batch-specific Certificate of Analysis confirming 99%+ purity via HPLC and mass spectrometry.
How should I store 5-Amino-1MQ before and after reconstitution?
Keep the lyophilized vial frozen and away from light. After reconstitution, refrigerate the solution and use it within the general stability window described in our storage guide.
Is 5-Amino-1MQ the same as a peptide?
No. It is a small organic molecule rather than an amino-acid chain, though it is commonly sold and studied alongside peptides because it targets a related area of cellular metabolism.
Does PSPeptides provide documentation with each order?
Yes. Every 5-Amino-1MQ vial ships with access to its batch-specific Certificate of Analysis so researchers can verify identity and purity before use. This is included automatically whenever you buy 5-Amino-1MQ from PSPeptides.
Can I buy 5-Amino-1MQ for use in a multi-compound research stack?
Yes, many labs order 5-Amino-1MQ specifically to run alongside other metabolic or mitochondrial research compounds. See our stacking guide above for general design considerations.
What documentation should I keep after I buy 5-Amino-1MQ?
Keep the Certificate of Analysis, order confirmation, and any lab notes on reconstitution and storage dates together with your research records for traceability.
Is 5-Amino-1MQ the same across every batch?
Formulation is consistent, but potency and purity are always confirmed per batch through independent testing rather than assumed from a prior batch’s results.
Can I request the Certificate of Analysis before I buy 5-Amino-1MQ?
Yes, contact PSPeptides support and a member of the team can help direct you to the relevant batch documentation for your order.
Does PSPeptides ship 5-Amino-1MQ internationally?
Shipping availability varies by destination. Check the shipping information at checkout or contact support to confirm whether international shipping applies to your order.
What should I check before I buy 5-Amino-1MQ from any vendor?
Confirm the vendor provides a batch-specific Certificate of Analysis, discloses manufacturing origin, and offers documented third-party testing rather than relying on marketing claims alone.
Related Resources
All PSPeptides products, including 5-Amino-1MQ, are sold exclusively for laboratory and research use. Not intended for human consumption.
Made & Shipped
Cellular Energy & Longevity Research Peptides
Cellular Energy & Longevity Research Peptides
Cellular Energy & Longevity Research Peptides