CJC-1295 is a synthetic analogue of growth hormone releasing hormone (GHRH), designed to stimulate the anterior pituitary gland to release growth hormone (GH). When researchers buy CJC-1295 with DAC, they gain access to the DAC (Drug Affinity Complex) modification — a lysine-reactive albumin-binding moiety that extends the peptide’s biological half-life from approximately 30 minutes to 6–8 days.
This dramatically extended half-life is the defining feature of CJC-1295 with DAC. It allows for less frequent dosing intervals while maintaining consistent elevation of serum GH and IGF-1 levels throughout the research window. To understand CJC-1295 within the broader GH secretagogue landscape, see our CJC-1295 and ipamorelin growth hormone guide.
Detailed Mechanism of Action
When researchers buy CJC-1295 with DAC, they are acquiring a peptide that operates through highly specific receptor-mediated pathways. CJC-1295 binds to the GHRH receptor (GHRHR) expressed on somatotropic cells in the anterior pituitary gland. This receptor is a G-protein coupled receptor (GPCR) that, upon activation, stimulates adenylyl cyclase and raises intracellular cyclic AMP (cAMP) concentrations.
The elevated cAMP activates protein kinase A (PKA), which phosphorylates downstream targets including the transcription factor CREB. This cascade ultimately drives both the synthesis of new growth hormone molecules and the release of pre-formed GH stored in secretory granules. The net result is a marked elevation in circulating GH levels that persists far longer than endogenous GHRH pulses.
The DAC modification — the “Drug Affinity Complex” — is a maleimide-functionalized fatty acid chain that covalently binds to lysine residues or the free cysteine on CJC-1295. Once conjugated, the DAC moiety enables reversible binding to serum albumin (the most abundant protein in blood plasma). This albumin association protects the peptide from proteolytic degradation and renal filtration, extending its effective half-life from roughly 30 minutes (for non-DAC CJC-1295) to approximately 6–8 days in vivo.
Researchers who buy CJC-1295 with DAC benefit from this pharmacokinetic profile: a single dose creates a prolonged “GH pulse train,” with pulsatile secretion occurring over several days. This contrasts with non-DAC formulations that produce sharper, shorter GH spikes. Whether one formulation is more suitable depends on the research model and endpoints being studied. For a full comparison of peptide half-lives, consult our peptide half-life reference chart.
Published Research on CJC-1295 With DAC
The scientific foundation for those who buy CJC-1295 with DAC rests on a well-documented body of peer-reviewed research. Ionescu and Frohman (2006) published a pivotal clinical study demonstrating that CJC-1295 with DAC produced dose-dependent and sustained elevations in GH and IGF-1 over multiple days in healthy adults. Peak GH levels increased 2- to 10-fold from baseline, and mean IGF-1 concentrations remained elevated for up to 14 days after a single dose — a remarkable pharmacokinetic achievement for a peptide. See this data at PubMed PMID 16983355.
Subsequent preclinical investigations confirmed CJC-1295 with DAC’s efficacy in rodent models of GH deficiency. Studies showed that weekly or biweekly administration maintained therapeutic IGF-1 ranges without the receptor desensitization seen with continuous GHRH infusions. This pulsatile-preserving pharmacology is mechanistically important for researchers studying natural GH axis regulation.
Additional animal studies explored the impact on body composition. In GH-deficient rat models, administration of buy CJC-1295 with DAC analogues resulted in reduced adipose tissue accumulation and preserved lean body mass over 8-week periods. These findings have implications for research into metabolic syndrome, age-related body composition changes, and GH replacement strategies. Further context on GH peptide research can be found in our complete research peptide guide.
A 2019 review in Journal of Clinical Endocrinology highlighted modified GHRH peptides — including buy CJC-1295 with DAC class compounds — as promising tools for studying somatopause (the age-related decline in GH secretion). The review noted their superior tolerability and pharmacokinetic profiles versus recombinant GH, making them valuable research comparators. Additional data available at PubMed PMID 30958560.
CJC-1295 With DAC vs. Alternatives
| Feature | CJC-1295 With DAC | CJC-1295 No DAC | Sermorelin |
|---|
| Half-life | 6–8 days | 30 min | 10–20 min |
| Dosing Frequency | Weekly or biweekly | Daily | Daily |
| GH Pulse Preservation | Moderate | Strong | Strong |
| IGF-1 Elevation Duration | Up to 14 days | 1–2 days | 1 day |
| Albumin Binding | Yes (via DAC) | No | No |
| Peptide Length | 30 amino acids | 30 amino acids | 29 amino acids |
| Research Use Case | Sustained GH models | Acute GH models | Acute GH models |
| Combined With Ipamorelin? | Common | Very common | Common |
Researchers who buy CJC-1295 with DAC often pair it with a GHRP-class peptide like ipamorelin to create synergistic GH release. While CJC-1295 with DAC acts on the GHRH receptor, ipamorelin acts on the ghrelin receptor (GHS-R) — the two signals amplify each other. Our CJC-1295 / ipamorelin stacking guide covers combination protocols in detail.
Reconstitution & Handling
Every vial purchased when you buy CJC-1295 with DAC from PSPeptides arrives as a lyophilized (freeze-dried) white powder sealed under nitrogen. Before use in any research application, the peptide must be reconstituted with sterile bacteriostatic water.
Recommended reconstitution protocol: Add bacteriostatic water slowly down the side of the vial — never directly onto the lyophilized cake. Gently swirl (do not shake or vortex) until fully dissolved. A common starting concentration for CJC-1295 with DAC research is 2mg/mL, achieved by adding 2.5mL bacteriostatic water to a 5mg vial. For step-by-step visual instructions, see our complete peptide reconstitution guide. Use our free peptide reconstitution calculator to compute exact volumes for any target concentration.
Once reconstituted, store the solution refrigerated at 2–8°C and use within 28 days. Handle all reconstituted peptides with sterile technique throughout. Aliquot into smaller volumes if long-term storage of reconstituted solution is required — freeze aliquots at -20°C to extend usable life. Never refreeze thawed aliquots.
Storage & Stability
Proper storage is critical to maintaining the integrity of any buy CJC-1295 with DAC research lot. Lyophilized vials are stable at room temperature for short periods during shipping, but should be stored at -20°C upon receipt for maximum shelf life. Protect from light and moisture.
Reconstituted CJC-1295 with DAC is stable for up to 28 days when stored at 2–8°C in a refrigerator. Avoid repeated freeze-thaw cycles. For a comprehensive reference on maintaining peptide potency over time, read our peptide storage guide and our how to tell if a peptide has degraded guide.
Certificate of Analysis
Every batch of buy CJC-1295 with DAC from PSPeptides ships with a batch-specific Certificate of Analysis (COA). This document includes HPLC chromatography data confirming the purity percentage and mass spectrometry data confirming molecular identity. We provide COAs transparently — not as afterthoughts.
Understanding how to read a COA is essential for any serious researcher. Our guide to reading a peptide COA walks through each section of the document, explains what the numbers mean, and flags what to look for when evaluating any peptide supplier’s test documentation.
Why Researchers Choose PSPeptides
- US Manufactured: All peptides, including every vial of buy CJC-1295 with DAC, are synthesized in US-based, FDA-registered facilities under strict GMP-aligned quality controls.
- Third-Party Tested: Independent HPLC and mass spectrometry verification on every batch — not just periodic spot checks. Results available before shipment.
- Fast Shipping: Free UPS 2nd Day Air on orders over $200, with same-day dispatch for orders placed before 2 PM EST. Track your order in real time.
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- 7-Day Support: Customer service available 7 days per week via email. Our team includes researchers who understand the science.
For a full comparison of peptide vendors, see our independent best peptide companies 2026 review and our guide on how to choose a research peptide supplier.
Frequently Asked Questions
What is the difference between CJC-1295 with DAC and CJC-1295 without DAC?
The key difference is half-life. Buy CJC-1295 with DAC and you get a peptide that binds serum albumin via its Drug Affinity Complex (DAC) modification, extending its half-life to 6–8 days. CJC-1295 without DAC (also called Mod GRF 1-29) has a half-life of about 30 minutes. The with-DAC version is preferred for sustained, long-duration GH elevation studies; the no-DAC version is used for acute, pulsatile GH protocols, often in combination with a GHRP like ipamorelin.
How many uses are in a 5mg vial of CJC-1295 with DAC?
At a standard research concentration of 2mg/mL (prepared by adding 2.5mL bacteriostatic water), each 5mg vial yields 2.5mL of solution — equivalent to 25 doses of 100mcg each, or 12-13 doses of 200mcg each. Use our free peptide dosage calculator guide to calculate volumes for any target dose and concentration.
Can I stack CJC-1295 with DAC with other peptides?
Yes — researchers commonly pair buy CJC-1295 with DAC alongside GHRP-class peptides such as ipamorelin, GHRP-2, or GHRP-6. These act via complementary receptor pathways (GHRHR vs. GHS-R), producing synergistic GH release amplification. For stacking principles, read our peptide stacking guide. Some researchers also include CJC-1295 with DAC in broader recovery stacks alongside BPC-157 or TB-500.
How should I store CJC-1295 with DAC after reconstitution?
Store reconstituted buy CJC-1295 with DAC at 2–8°C (standard refrigerator temperature) and use within 28 days. Keep away from light, and do not shake the vial. Store the lyophilized (unreconstituted) vial at -20°C for long-term storage. Review our complete peptide storage guide for best practices on maintaining peptide potency throughout your research protocol.
Is CJC-1295 with DAC legal to buy for research?
In the United States, buy CJC-1295 with DAC is legal to purchase for laboratory and in vitro research purposes. It is not approved for human use by the FDA. Researchers should review their institutional guidelines and local regulations before ordering. See our updated research peptides legal status guide for 2026 for current regulatory context.
CJC-1295 With DAC and the GH-IGF-1 Axis: A Research Deep-Dive
For researchers who buy CJC-1295 with DAC to study growth hormone physiology, understanding the full GH-IGF-1 axis is essential context. GH itself is a 191-amino-acid protein secreted by somatotrophs in the anterior pituitary. Its secretion is tightly regulated by two opposing hypothalamic peptides: GHRH (stimulatory) and somatostatin (inhibitory). CJC-1295 with DAC mimics the stimulatory side of this equation.
Once secreted, GH travels through the bloodstream and binds to GH receptors in the liver, skeletal muscle, adipose tissue, and bone. In the liver, GH binding triggers production of insulin-like growth factor 1 (IGF-1), which is the primary downstream effector of most of GH’s anabolic actions. IGF-1 promotes protein synthesis, inhibits protein degradation, stimulates cell proliferation, and modulates glucose metabolism in peripheral tissues.
Researchers who buy CJC-1295 with DAC are studying this entire cascade. The sustained GH elevation produced by CJC-1295 with DAC’s long half-life creates a prolonged anabolic environment in animal models — useful for studying chronic GH stimulation effects that would be difficult to replicate with short-acting peptides requiring multiple daily administrations.
The somatotropic axis also interacts with other endocrine systems. GH and IGF-1 influence insulin sensitivity, thyroid function, cortisol metabolism, and sex hormone pathways. Longitudinal studies using buy CJC-1295 with DAC protocols can probe these cross-axis interactions in ways that short-acting secretagogues cannot. For researchers interested in the broader peptide landscape, our comprehensive peptide glossary defines key terms used throughout the GH research literature.
Peptide Purity Standards: Why It Matters When You Buy CJC-1295 With DAC
Not all research peptides are created equal. When laboratories buy CJC-1295 with DAC from different sources, purity and impurity profiles can vary substantially — and these differences directly impact experimental validity. A peptide with 85% purity contains 15% unknown impurities that may exert their own biological effects, confounding research results.
PSPeptides uses independent third-party analytical laboratories to verify every batch. Our HPLC (High Performance Liquid Chromatography) testing separates the peptide from contaminants by molecular weight and confirms the target peak accounts for 99%+ of the sample. Mass spectrometry then confirms molecular identity by verifying the exact molecular weight matches the expected formula for buy CJC-1295 with DAC.
These are not nominal purity claims — they are documented in batch-specific COAs that ship with every order. Researchers who need to cite purity data in publications or institutional reports can use PSPeptides’ COAs as supporting documentation. To understand exactly what our testing verifies and how to interpret COA data, read our detailed peptide purity and COA interpretation guide.
Common Research Models Using CJC-1295 With DAC
Researchers who buy CJC-1295 with DAC employ it across a wide range of preclinical models. Here is an overview of the most common experimental frameworks where CJC-1295 with DAC is utilized:
Rodent GH Deficiency Models: Hypophysectomized (pituitary-removed) rats or GH receptor knockout mice are frequently used to study exogenous GH stimulation. Buy CJC-1295 with DAC administration in these models allows researchers to titrate GH levels systematically and observe downstream effects on bone density, muscle mass, adiposity, and metabolic markers.
Aging Animal Models: Aged rats and mice naturally exhibit reduced GHRH signaling and pulsatile GH secretion — a state called somatopause that mirrors the decline seen in aging humans. Administering buy CJC-1295 with DAC in these models helps researchers evaluate whether restoring GH-IGF-1 axis activity can mitigate age-related physiological decline. Relevant context is in our longevity peptide research guide.
Sleep-GH Coupling Studies: The largest natural GH pulse in mammals occurs during deep slow-wave sleep. Researchers studying buy CJC-1295 with DAC effects on sleep architecture use polysomnography alongside plasma GH measurements to characterize whether extended GHRH stimulation alters sleep stage distribution. Explore related peptide research in our peptides for sleep and recovery guide.
Metabolic Research: GH has complex bidirectional effects on glucose homeostasis — acutely raising blood glucose while chronically improving insulin sensitivity at physiological levels. CJC-1295 with DAC studies in obese or diabetic animal models investigate whether sustained GH stimulation alters fat distribution, liver lipid metabolism, or pancreatic beta-cell function.
Related Resources
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