CJC-1295 No DAC (also sold as Mod GRF 1-29) is a 29-amino-acid growth hormone releasing hormone (GHRH) analog that signals the pituitary through the GHRH receptor. Ipamorelin is a five-amino-acid growth hormone secretagogue that works through the ghrelin (GHS-R1a) receptor.
Because the two compounds drive growth hormone release through separate pathways, laboratories buy CJC 1295 Ipamorelin blend as a single pre-matched reagent rather than sourcing each peptide on its own. Our complete CJC-1295 + Ipamorelin guide covers the full background.
Detailed Mechanism of Action
CJC-1295 No DAC binds the GHRH receptor on pituitary somatotrophs, a G-protein-coupled receptor that activates adenylyl cyclase and raises intracellular cAMP. The rise in cAMP triggers protein kinase A signaling, opens calcium channels, and drives exocytosis of stored growth hormone.
Four amino-acid substitutions at positions 2, 8, 15, and 27 protect the peptide from the DPP-IV enzyme that rapidly degrades native GRF 1-29. The result is roughly 30 minutes of activity while the signal stays pulsatile — the property most pulse-timing protocols are built around.
Ipamorelin takes a different route. As a selective agonist of the ghrelin receptor (GHS-R1a), it activates phospholipase C and inositol trisphosphate signaling, mobilizing calcium from intracellular stores. It also suppresses somatostatin, the hypothalamic brake on GH output. The net effect is a second, independent push on the same somatotroph population that the GHRH analog is already stimulating.
When both compounds are present, the GH response is synergistic rather than merely additive. The GHRH receptor increases the amount of GH available for release while the ghrelin receptor increases the probability and amplitude of release. This two-receptor convergence is the core reason research groups buy CJC 1295 Ipamorelin blend as a combined vial: a single reagent removes a variable from the protocol.
Equally important is what the blend does not do. Older secretagogues such as GHRP-2 and GHRP-6 bind more promiscuously and raise cortisol, ACTH, and prolactin. Ipamorelin’s selectivity, first described by Raun and colleagues in 1998, avoids that collateral signaling, so the GH readout in a model is cleaner — a key reason to buy CJC 1295 Ipamorelin blend instead of a GHRP-6 pairing.
Our peptide half-life chart lists the relevant pharmacokinetic windows for each compound so you can plan sampling intervals before the vial arrives.
Published Research
The most-cited human data on the CJC-1295 scaffold comes from Teichman and colleagues (2006). A single injection of the long-acting DAC form raised mean plasma GH two- to ten-fold for six days or more, with IGF-1 elevated 1.5- to three-fold for nine to eleven days and an estimated half-life of 5.8 to 8.1 days (PubMed 16352683).
The No DAC version in this vial shares that receptor pharmacology but not the albumin binding, which is why its activity window is measured in minutes rather than days.
Ionescu and Frohman (2006) further showed that pulsatile GH secretion persisted even under continuous GHRH-receptor stimulation by CJC-1295, confirming that rhythmic pituitary output is preserved rather than flattened (PubMed 17018654). That finding underpins the pulse-research use case for which most laboratories buy CJC 1295 Ipamorelin blend in the short-acting form.
On the Ipamorelin side, Raun et al. (1998) characterized the pentapeptide as the first selective growth hormone secretagogue, releasing GH with potency comparable to GHRP-6 while leaving ACTH, cortisol, prolactin, FSH, LH, and TSH unchanged in animal models (PubMed 9849822). Teams that buy CJC 1295 Ipamorelin blend for replication or extension studies can cite these three papers directly as the mechanistic rationale for GHRH + GHRP co-administration.
CJC 1295 Ipamorelin Blend vs Alternatives
Researchers deciding whether to buy CJC 1295 Ipamorelin blend or a single-compound alternative usually weigh pulsatility, selectivity, and handling. The table below compares the most common options sold in the research market.
| Feature | CJC-1295 No DAC + Ipamorelin (this product) | CJC-1295 with DAC | MK-677 (Ibutamoren) |
|---|
| Receptor pathways | GHRH-R + GHS-R1a (dual) | GHRH-R only | GHS-R1a only |
| Active window | ~30 min (CJC) / ~2 h (Ipamorelin) | 5.8–8.1 days | ~24 h (oral) |
| GH release pattern | Pulsatile, synergistic | Sustained GH/IGF-1 elevation | Sustained, amplified pulses |
| Cortisol / prolactin effect | Minimal (Ipamorelin selective) | Minimal | Modest cortisol rise reported |
| Appetite signaling | Low | None | Strong (ghrelin mimetic) |
| Form | Lyophilized, reconstitute with BAC water | Lyophilized | Oral solution or capsule |
| Best suited for | Pulse-timing and synergy studies | Long-exposure IGF-1 models | Oral-route, long-duration models |
| Availability at PSPeptides | In stock — this page | See catalog | See MK-677 guide |
Sermorelin paired with GHRP-2 is the older version of this stack. It works, but GHRP-2 raises cortisol and prolactin, and Sermorelin lacks the DPP-IV-resistant substitutions. That is the main reason laboratories that once ran Sermorelin/GHRP-2 now buy CJC 1295 Ipamorelin blend instead. For broader combinations, see our peptide stacking guide.
Who Should Buy CJC 1295 Ipamorelin Blend?
University and hospital research groups buy CJC 1295 Ipamorelin blend when a protocol calls for a documented, lot-traceable GHRH + GHRP reagent. The batch-specific COA, US origin, and consolidated invoicing make procurement and IRB paperwork simpler than sourcing two peptides from two vendors.
Contract research organizations and private laboratories buy CJC 1295 Ipamorelin blend in multi-vial quantities for assay development and comparative secretagogue studies. Same-day dispatch and free 2nd Day Air over $200 keep study timelines on schedule, and bulk quotations are available on request.
Independent researchers running smaller GH-axis studies buy CJC 1295 Ipamorelin blend because a single 10mg vial, two milliliters of bacteriostatic water, and a dosage calculator are enough to run a complete protocol. Split-pay options through Afterpay and Klarna keep the up-front cost manageable.
Research Protocol Considerations
Because CJC-1295 No DAC is active for about 30 minutes and Ipamorelin for about two hours, most protocols time administration to coincide with a natural GH pulse window and sample serum at 15, 30, 60, and 120 minutes afterward. The fixed 1:1 ratio in this vial means the two compounds are always delivered in the same proportion, which removes a preparation variable between sessions.
Researchers who buy CJC 1295 Ipamorelin blend for multi-week studies typically log reconstitution date, concentration, and lot number on each vial and in a shared spreadsheet. Our cycling guide and peptide side effects overview cover the study-design questions that come up most often.
Reconstitution & Handling
The vial arrives as a lyophilized cake. To reconstitute, wipe the stopper with an alcohol pad, then slowly inject bacteriostatic water down the inside wall of the vial so the stream does not hit the powder directly. Swirl gently until the solution is clear — never shake, which can shear the peptide chains.
Two milliliters of bacteriostatic water yields 5 mg/mL total peptide (2.5 mg/mL of each compound); one milliliter yields 10 mg/mL total. Our step-by-step peptide reconstitution guide walks through the process with photos, and the dosage calculator tutorial shows how to convert a target microgram amount into a syringe draw volume.
Use sterile, single-use insulin syringes (28–31 gauge) for each draw and never re-enter the vial with a used needle. Label the vial with the reconstitution date and concentration. Teams that buy CJC 1295 Ipamorelin blend in multi-vial quantities usually reconstitute one vial at a time and keep the rest lyophilized to maximize shelf life.
Storage & Stability
Lyophilized, the blend is stable for 24 months or longer when refrigerated at 2–8°C and kept away from light and humidity, which is why you can buy CJC 1295 Ipamorelin blend in quantity without worrying about near-term expiry. Short exposures to room temperature during shipping do not compromise the powder, so the vial ships without a cold pack.
Once reconstituted with bacteriostatic water, store at 2–8°C and use within 28 days, away from the refrigerator door to avoid temperature cycling. Avoid freezing reconstituted solution — ice crystals degrade both peptides. Signs of degradation include cloudiness, visible particulates, or a yellow tint. Our peptide storage guide and degradation detection article cover handling in more detail.
Certificate of Analysis
Every lot of this blend is tested by an independent laboratory using reverse-phase HPLC for purity and mass spectrometry for identity confirmation of both the CJC-1295 No DAC and Ipamorelin sequences. The COA lists the lot number, test date, purity percentage, observed versus theoretical molecular weight, and appearance. A printed copy ships with the order, and you can request the PDF by lot number at any time.
If you are comparing suppliers before you buy CJC 1295 Ipamorelin blend, insist on a batch-specific COA rather than a generic sample document. Our COA reading guide explains what the chromatogram should look like and which red flags indicate an untested product.
Why Researchers Choose PSPeptides
Here is what you get every time you buy CJC 1295 Ipamorelin blend from PSPeptides:
- US Manufactured: Synthesized and lyophilized in US facilities with chain-of-custody documentation from synthesis to shipment.
- Third-Party Tested: Independent HPLC and mass spectrometry on every batch — never in-house-only claims.
- Fast Shipping: Free UPS 2nd Day Air over $200, same-day dispatch before 2 PM EST, discreet packaging.
- Flexible Payments: Credit cards, Afterpay, Klarna, Apple Pay, Google Pay.
- 7-Day Support: Email, phone, or text — real answers from people who handle the product daily.
- Transparent Sourcing: Read how to choose a research peptide supplier and hold us to the same standard.
What You Receive
Each order includes one sealed 10mg vial (5mg CJC-1295 No DAC + 5mg Ipamorelin), the batch-specific Certificate of Analysis, and a packing slip referencing the lot number for traceability. The vial is packed in a crush-resistant, discreet mailer with no exterior product labeling. When you buy CJC 1295 Ipamorelin blend in multi-vial quantities, all vials ship lot-matched from the same batch whenever possible.
Ordering, Shipping & Payment
Buy CJC 1295 Ipamorelin blend before 2 PM EST Monday through Friday and it leaves our facility the same business day. Domestic shipments travel via UPS, with 2nd Day Air free on orders over $200 and tracking emailed at dispatch. The lyophilized vial travels safely at ambient temperature. Bulk and institutional buyers can request a volume quotation and expedited freight by contacting support before checkout.
Checkout accepts all major credit cards, Apple Pay, and Google Pay, plus Afterpay and Klarna for split payments on larger orders. When you buy CJC 1295 Ipamorelin blend alongside bacteriostatic water, syringes, and other supplies, everything ships together in one tracked package. International researchers should confirm local importation rules before ordering; see are research peptides legal in 2026 for an overview of the current regulatory landscape.
Compatible Research Supplies
Most laboratories pair this vial with sterile bacteriostatic water, U-100 insulin syringes (28–31 gauge), alcohol prep pads, and a sharps container. A dosage calculator or shared spreadsheet keeps draw volumes consistent across the team. For researchers who prefer a non-injectable format, PSPeptides also stocks a CJC No DAC + Ipamorelin intranasal spray that can be ordered on the same ticket.
An under-counter laboratory refrigerator held at 2–8°C is sufficient for storage. Avoid household freezers, which cycle through wide temperature ranges. If you plan to buy CJC 1295 Ipamorelin blend as part of a larger GH-axis study, our complete guide to peptides and subcutaneous vs intramuscular injection article are useful protocol references.
Frequently Asked Questions
Where can I buy CJC 1295 Ipamorelin blend online?
You can buy CJC 1295 Ipamorelin blend directly from this page. Choose your quantity, add to cart, and check out with a card, Apple Pay, Google Pay, Afterpay, or Klarna. Orders before 2 PM EST ship the same day with tracking, and every vial includes a batch-specific COA.
What is the difference between CJC-1295 No DAC and CJC-1295 with DAC?
The DAC (Drug Affinity Complex) version binds albumin in circulation and stays active for about a week, producing sustained GH and IGF-1 elevation. The No DAC version in this blend acts for roughly 30 minutes, producing a discrete pulse. Researchers who need timing control over individual GH pulses buy CJC 1295 Ipamorelin blend in the No DAC form.
Is it cheaper to buy CJC 1295 Ipamorelin blend than two separate vials?
Usually, yes. One combined 10mg vial costs less than buying a 5mg CJC-1295 No DAC vial and a 5mg Ipamorelin vial separately, uses one vial of bacteriostatic water instead of two, and ships as a single line item. It also guarantees the 1:1 ratio without manual mixing.
Can both peptides be reconstituted together in one vial?
Yes — the two compounds are co-lyophilized in this vial at a 1:1 ratio and are chemically compatible in bacteriostatic water. There is no need to purchase and mix separate vials, and every draw delivers both peptides in the same proportion.
How much bacteriostatic water should I add?
Two milliliters is the most common volume, giving 5 mg/mL total peptide (2.5 mg/mL of each). One milliliter doubles the concentration. Use our dosage calculator to match concentration to your protocol’s draw volumes.
What testing comes with each vial?
Each lot is tested by an independent laboratory using HPLC for purity and mass spectrometry for identity. The batch-specific COA ships with your order, and PDF copies are available on request by lot number.
How fast will my order arrive?
Domestic orders placed before 2 PM EST ship the same business day via UPS. Orders over $200 qualify for free 2nd Day Air, so most US laboratories receive the vial within two business days. International delivery times vary by destination and customs processing.
Can I buy CJC 1295 Ipamorelin blend in bulk for a laboratory?
Yes. Laboratories that buy CJC 1295 Ipamorelin blend in multi-vial quantities can contact support by email, phone, or text for a volume quotation before placing the order. Bulk shipments include a consolidated COA packet and lot-matched vials so your inventory records stay simple.
Related Resources
All PSPeptides products are sold exclusively for laboratory and research use. Not intended for human consumption.
Made & Shipped
