KPV is a synthetic tripeptide of lysine, proline, and valine — residues 11-13 of alpha-melanocyte-stimulating hormone (α-MSH). Despite its tiny size, KPV is one of the most studied anti-inflammatory peptide fragments, investigated for its ability to suppress NF-κB signaling and reduce pro-inflammatory cytokine release in gut, skin, and lung models. Read our complete KPV anti-inflammatory guide before you buy KPV for your lab.
Ready to buy KPV? Select your vial size above, add to cart, and check out with credit card, Afterpay, Klarna, Apple Pay, or Google Pay. Need the full research dossier first? Open the extended description below.
Why Buy KPV Peptide from PSPeptides?
When you buy KPV from PSPeptides, you are buying a US-manufactured tripeptide that has been independently verified before it ever reaches your bench. Every lot is run through third-party HPLC for purity and mass spectrometry for identity, and the resulting batch COA ships with your vial. No anonymous overseas stock, no missing paperwork, no guessing.
Just as important, you buy KPV at a price that makes repeat and multi-vial ordering practical. The 10mg vial is $39.99, the 20mg vial is $59.99, and orders over $200 ship free by UPS 2nd Day Air. Researchers who compare us against the suppliers in our 2026 best peptide companies review consistently find the same purity at a lower landed cost.
- 99%+ purity, verified independently: HPLC and MS on every batch, not just a one-time spec sheet.
- Batch COA included: Chromatogram, mass confirmation, and lot number for your records.
- US manufactured: Synthesized and lyophilized domestically under strict quality controls.
- Same-day dispatch: Buy KPV before 2 PM EST and it leaves the warehouse the same business day.
- Flexible checkout: Credit cards, Afterpay, Klarna, Apple Pay, and Google Pay.
- 7-day support: Reach our research-trained team by email, phone, or text.
How to Buy KPV Online in Three Steps
Step 1 — pick your size. Use the selector above the Add to Cart button to choose the 10mg or 20mg vial. Labs running a single pilot assay usually buy KPV 10mg; groups planning a multi-week colitis or dermal study typically choose 20mg for the lower cost per milligram.
Step 2 — add reconstitution supplies. KPV ships as a lyophilized powder, so add bacteriostatic water to the same order if your lab does not already stock it. Bundling supplies is also the easiest way to pass the $200 free-shipping threshold.
Step 3 — check out securely. Pay by card or use Afterpay or Klarna to split the cost. You will receive an order confirmation immediately and UPS tracking as soon as the package leaves our facility. That is all it takes to buy KPV peptide online from a supplier you can verify.
What Arrives in Your Order
Each order contains a sealed glass vial of lyophilized KPV peptide (10mg or 20mg) with a crimped cap and flip-off seal, the batch-specific Certificate of Analysis for that lot, and protective packaging that keeps the vial secure in transit. The powder appears as a white to off-white cake at the bottom of the vial.
Because the peptide is freeze-dried, no cold packs are required for domestic shipping, and the vial can go straight into your -20°C freezer on arrival. If you also buy KPV reconstitution supplies in the same order, the bacteriostatic water ships in the same box.
KPV Pricing, Vial Sizes & Bundles
PSPeptides prices KPV to be the easiest anti-inflammatory tripeptide to add to any research budget. A single 10mg vial is $39.99, and the 20mg vial is $59.99 — a 25% saving per milligram when you buy KPV in the larger size. There are no hidden handling fees, and the COA is always included at no extra charge.
If your protocol calls for a different format, the same 99%+ KPV is also available as a ready-to-use KPV Spray and in our GHK-Cu + KPV Blend for combined skin-and-inflammation research. Many labs buy KPV vials together with BPC-157 for gut-focused work, which also unlocks free 2nd Day Air shipping.
Bulk & Repeat Orders for Laboratories
Planning a longer study? Multi-vial orders are the most economical way to buy KPV peptide at PSPeptides: five 10mg vials, or four 20mg vials, clear the $200 free-shipping threshold on their own. Wherever possible we fill multi-vial orders from a single lot so every vial in your study shares the same COA and purity profile.
Labs that reorder regularly can simply return to this page and buy KPV 10mg or 20mg again — your saved account details make reordering quick. For institutional quantities or custom documentation requests, contact our support team by email, phone, or text seven days a week and we will put together a quote.
Detailed Mechanism of Action
KPV corresponds to the C-terminal tripeptide (positions 11-13) of the 13-amino-acid neuropeptide α-MSH. Hiltz and Lipton first reported in 1989 that this tiny fragment retained the anti-inflammatory activity of the full hormone, which launched more than three decades of research into KPV as a minimal anti-inflammatory motif.
Unlike full-length α-MSH, KPV lacks the His-Phe-Arg-Trp core required for high-affinity melanocortin receptor binding. Its anti-inflammatory signaling is therefore thought to be largely receptor-independent. In intestinal epithelial and immune cells, KPV is actively transported across the membrane by the oligopeptide transporter PepT1, after which it interferes with inflammatory signaling inside the cell.
The central downstream target is NF-κB. In stimulated cells, KPV reduces IκB degradation and nuclear translocation of the p65 subunit, limiting transcription of IL-6, IL-8, TNF-α, and adhesion molecules. Inhibition of MAP-kinase phosphorylation has also been described, which helps explain why KPV blunts cytokine release from several different cell types rather than from a single lineage.
Secondary effects reported in the literature include reduced neutrophil recruitment and myeloperoxidase activity in inflamed tissue, and direct antimicrobial activity against Candida albicans and Staphylococcus aureus. Researchers who buy KPV for dermal or gut models often cite this combination of anti-inflammatory and antimicrobial activity as the reason they chose the tripeptide over broader immunosuppressive tools.
Published Research on KPV
The most-cited KPV study is Dalmasso et al. (2008), published in Gastroenterology. The authors showed that KPV is taken up by intestinal epithelial and immune cells through PepT1, that it inhibits NF-κB and MAP-kinase activation and pro-inflammatory cytokine secretion in vitro, and that orally delivered KPV reduced the severity of DSS-induced colitis in mice.
In the same year, Kannengiesser et al. (2008) reported in Inflammatory Bowel Diseases that KPV had anti-inflammatory potential in murine models of IBD, reducing clinical and histological markers of colitis. Together these two papers are why most groups that buy KPV today are working in intestinal inflammation.
The broader framework comes from Luger and Brzoska (2007), who reviewed α-MSH-related peptides, including KPV, as a new class of anti-inflammatory and immunomodulating agents acting through NF-κB inhibition and cytokine down-regulation.
Later cell-culture work by Land (2012) extended the KPV peptide mechanism to human bronchial epithelial cells, and Cutuli et al. (2000) documented the antimicrobial effects of α-MSH fragments. See our peptides for gut health research guide for a plain-language summary of what this literature means for study design.
Which KPV Product Should You Buy? Vial vs Spray vs GHK-Cu Blend
| Feature | KPV (1 Vial) | KPV Spray | GHK-Cu + KPV Blend |
|---|
| Form | Lyophilized powder | Ready-to-use solution | Lyophilized blend |
| Amount | 10mg or 20mg | Metered spray | Combined vial |
| Price | From $39.99 | $59.99 | $59.99 |
| Reconstitution needed | Yes (bacteriostatic water) | No | Yes |
| Best for | Precise concentration control, cell and animal models | Convenience, no mixing | Skin, hair, and inflammation research |
| Cost per mg | Lowest | Moderate | Moderate |
| Purity & COA | 99%+, COA included | 99%+, COA included | 99%+, COA included |
| Shipping | Same-day before 2 PM EST | Same-day before 2 PM EST | Same-day before 2 PM EST |
For most laboratories the lyophilized vial is the right place to start: it offers the lowest cost per milligram and full control over final concentration. Buy KPV in the vial format when you need to titrate, and add the spray or blend later if a protocol calls for it.
Reconstitution & Handling
KPV is highly water-soluble thanks to its basic lysine residue, so reconstitution is straightforward. Let the vial reach room temperature, then slowly inject bacteriostatic water down the inside wall of the glass. Adding 1 mL to a 10mg vial yields 10 mg/mL (10,000 mcg/mL); adding 2 mL yields 5 mg/mL, which many labs find easier to measure accurately.
For the 20mg vial, 2 mL of bacteriostatic water gives the same 10 mg/mL working stock. Swirl gently until the solution is clear — never shake, which can shear the peptide. Our step-by-step reconstitution guide and the PSPeptides peptide calculator will convert any target concentration into exact volumes before you draw.
If you are new to lyophilized peptides, read what bacteriostatic water is and why it is preferred over sterile water for multi-draw vials. Most researchers buy KPV and a 30 mL bottle of bacteriostatic water together so the vial can be used across several weeks of experiments.
Storage & Stability
Store unopened lyophilized KPV at -20°C for long-term stability of 12 months or more; brief transit at ambient temperature does not degrade the freeze-dried powder, which is why we ship without ice packs. Keep the vial sealed and away from direct light until you are ready to reconstitute.
Once reconstituted, refrigerate at 2-8°C and use within 28 days. Avoid repeated freeze-thaw cycles, and discard any solution that turns cloudy or develops particulates.
If you buy KPV in the 20mg size, consider splitting the reconstituted stock into smaller aliquots so the main vial is not repeatedly warmed. For a deeper look at shelf life, temperature excursions, and how to recognize a compromised vial, see our peptide storage guide and peptide degradation checklist.
Certificate of Analysis
Every KPV vial ships with a batch-specific Certificate of Analysis from an independent laboratory. The COA reports HPLC purity (typically 99%+), mass spectrometry confirmation of the expected 342.4 g/mol molecular weight, the lot number, and the analysis date. Keep it with your study records to satisfy internal QC or IRB documentation requirements.
Not sure how to interpret a chromatogram? Our guide to reading a peptide COA walks through peak area, retention time, and what a legitimate mass-spec report should show. When you buy KPV from PSPeptides, you never have to request documentation after the fact — it is already in the box.
Shipping, Payments & Support
Orders placed before 2 PM EST on a business day ship the same day from our US facility. Orders over $200 ship free by UPS 2nd Day Air; smaller orders ship at the rate shown at checkout. Tracking is emailed automatically, and lyophilized vials are packed to protect the glass in transit.
We accept all major credit cards, Apple Pay, Google Pay, Afterpay, and Klarna, so labs can buy KPV now and split payments if needed. Questions before or after your order? Our support team answers email, phone, and text seven days a week — and if anything arrives damaged, contact us right away and we will help.
Why Researchers Choose PSPeptides
- US Manufactured: Every peptide, including KPV, is synthesized domestically under documented quality controls.
- Third-Party Tested: Independent HPLC and mass spectrometry verification on every batch.
- Fast Shipping: Free UPS 2nd Day Air over $200, same-day dispatch before 2 PM EST.
- Flexible Payments: Credit cards, Afterpay, Klarna, Apple Pay, Google Pay.
- 7-Day Support: Email, phone, or text — real answers from a research-trained team.
- Transparent Pricing: Buy KPV at $39.99 per 10mg vial with the COA included, no surprise fees.
Choosing a vendor is the single biggest variable in peptide research reproducibility. Our guide on how to choose a research peptide supplier explains the red flags to watch for, and why documented third-party testing matters more than marketing claims.
Stacking KPV with Other Research Peptides
KPV is frequently studied alongside other repair-oriented peptides. In gut research, labs pair it with BPC-157 to examine inflammation control and mucosal repair in the same model. In dermal work, the copper peptide GHK-Cu is the most common partner, which is why we also offer the two together in a single blended vial.
For systemic tissue-repair protocols, some groups buy KPV together with the Wolverine Blend (BPC-157 + TB-500). Our peptide stacking guide and immune-support peptide overview cover timing, concentration ratios, and how to design controls when more than one compound is in play.
Frequently Asked Questions
How much does it cost to buy KPV peptide?
A 10mg vial of KPV is $39.99 and a 20mg vial is $59.99 at PSPeptides, with the batch COA included. Orders over $200 ship free via UPS 2nd Day Air, so many labs buy KPV in multiples or add bacteriostatic water to reach the threshold.
Is it legal to buy KPV in the United States?
Yes. KPV is sold as a research chemical for in-vitro and laboratory use, and it is legal to purchase for that purpose. It is not an FDA-approved drug and is not intended for human consumption. Our article on whether research peptides are legal in 2026 explains the regulatory landscape in detail.
How fast will my KPV order ship?
Orders placed before 2 PM EST on a business day ship the same day with UPS tracking. Orders over $200 ship free by 2nd Day Air, so most US labs receive their KPV within two business days of ordering.
Should I buy KPV 10mg or 20mg?
The 10mg vial is ideal for pilot assays and single-experiment budgets. If your protocol runs over several weeks or across multiple animal groups, the 20mg vial lowers your cost per milligram by about 25% and reduces the number of reconstitutions you need to perform.
Do I need bacteriostatic water to use KPV?
Yes. KPV ships as a lyophilized powder and must be reconstituted before use. Bacteriostatic water contains 0.9% benzyl alcohol, which keeps a multi-draw vial usable for up to 28 days. Add a bottle to your cart when you buy KPV to avoid a second shipment.
Can KPV be combined with BPC-157 or GHK-Cu in research?
Many laboratories study KPV alongside BPC-157 for gut inflammation or GHK-Cu for skin research. Each peptide should be reconstituted separately and combined only at the point of use, with single-compound controls included in the study design. Our GHK-Cu + KPV Blend is available if a pre-combined vial fits your protocol.
How do I know the KPV I buy is genuine?
Check the batch COA: it should show HPLC purity above 99% and a mass-spec peak at 342.4 g/mol. PSPeptides includes this document with every order and manufactures in the US, so you can trace the vial on your bench back to a specific tested lot.
Related Resources
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