Description

Pure GHK-Cu Copper Peptide Topical Serum — 1% Concentration

A concentrated 1% GHK-Cu (glycyl-L-histidyl-L-lysine copper) topical serum formulated for skin research applications. GHK-Cu is the most extensively studied copper peptide in published scientific literature, with over 50 years of research documenting its effects on collagen synthesis, extracellular matrix remodeling, and skin regeneration pathways.

Product Specifications

• Concentration: 1% GHK-Cu
• Volume: 3mL
• Format: Ready-to-use topical serum (no reconstitution required)
• Appearance: Light blue tint (characteristic of copper peptide complex — indicates proper chelation)
• Storage: Room temperature, protected from direct sunlight

Why GHK-Cu for Skin Research?

GHK-Cu is a naturally occurring tripeptide-copper complex first identified in human blood plasma in 1973. It is the only peptide shown to influence approximately 4,000 human genes (~6% of the genome) in Broad Institute Connectivity Map analysis — making it one of the most broadly active signaling molecules studied in skin biology.

Published research demonstrates GHK-Cu’s effects on:

• Collagen synthesis — up to 70% increase in collagen production in vitro. A 12-week human clinical trial showed GHK-Cu outperformed both vitamin C and retinoic acid in measured collagen increases (Abdulghani et al.)
• Skin thickness and firmness — clinical studies documented significant improvements in skin density, elasticity, and laxity reduction
• Wound healing acceleration — promotes angiogenesis (new blood vessel formation) through VEGF upregulation, enhancing nutrient delivery to healing tissue
• Anti-inflammatory activity — suppresses pro-inflammatory cytokines including TNF-α, IL-6, and TGF-β, reducing oxidative damage and chronic skin inflammation
• Antioxidant defense — copper cofactor supports superoxide dismutase (SOD), a key enzyme protecting cells from free radical damage
• Gene expression modulation — activates genes associated with tissue repair, stem cell function, and extracellular matrix production while suppressing genes linked to tissue degradation

Topical vs Injectable GHK-Cu

This serum is designed for direct topical application — no reconstitution, no syringes required. Published clinical studies have confirmed that GHK-Cu penetrates the stratum corneum (outer skin barrier) in bioactive quantities when applied topically, making it effective for localized skin research without systemic administration.

For researchers requiring injectable GHK-Cu for systemic studies, PSPeptides also offers lyophilized GHK-Cu vials in 50mg and 100mg sizes.

How to Use

1. Cleanse the target skin area
2. Apply a thin layer of serum to the research area
3. Allow to absorb fully before applying other products (approximately 2-3 minutes)
4. Apply once or twice daily for consistent research protocols
5. Store at room temperature, away from direct sunlight

One 3mL bottle provides approximately 60 applications when using a standard single-drop application per area.

What Makes PSPeptides GHK-Cu Serum Different

• 1% concentration — research-grade concentration matching published clinical study protocols
• US manufactured — produced in FDA-registered facilities with pharmaceutical-grade quality controls
• Third-party tested — every batch verified via independent HPLC and mass spectrometry to 99%+ purity
• Ready to use — no reconstitution required, unlike lyophilized powder formulations
• Batch-specific COA — Certificate of Analysis published for every production batch on our Certifications page

Frequently Asked Questions

What does GHK-Cu serum do for skin?

Published research shows GHK-Cu stimulates collagen synthesis, improves skin thickness and elasticity, promotes wound healing through angiogenesis, and provides antioxidant protection. A clinical trial demonstrated it outperformed both vitamin C and retinoic acid for collagen production.

Why is the serum blue?

The light blue tint is characteristic of GHK-Cu’s copper complex and is a sign of proper peptide-copper chelation. This is expected and indicates an active formulation.

How long does one bottle last?

At once-daily application to a single area, a 3mL bottle lasts approximately 60 days. At twice-daily application, approximately 30 days.

How should I store the serum?

Room temperature, away from direct sunlight. No refrigeration required. Use within 6 months of opening.

Related Research & Products

• GHK-Cu Copper Peptide: The Science Behind Skin Regeneration →
• Best Peptides for Skin & Anti-Aging Research →
• GHK-Cu for Hair Loss: What Research Shows →
• GHK-Cu Lyophilized Powder (50mg / 100mg) →
• GLOW Blend — BPC-157 + GHK-Cu + TB-500 →
• KLOW Blend — BPC-157 + GHK-Cu + TB-500 + KPV →

References

1. Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015;2015:648108.
2. Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987.
3. Abdulghani AA, et al. Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin. Disease Management and Clinical Outcomes. 1998;1(4):136-141.
4. Arul V, et al. Wound healing effect of topical application of GHK-Cu on dermal wound models. Life Sci. 2007;80(14-15):1351-1355.

This product is for research and cosmetic evaluation purposes only.

PSPeptides — US Made & Shipped | Third-Party Tested | 99%+ Purity | Same-Day Shipping